早期先兆流产与糖类抗原125的相关性研究进展

早期先兆流产的发病率呈上升趋势,是产科重点关注疾病之一,应重视先兆流产的监测和治疗。通过对国内外相关研究文献的查阅和整理,发现糖类抗原125(cancer antigen 125,CA125)在早期先兆流产中逐渐被关注,血清CA125水平或有望成为早期先兆流产的预测和诊断指标之一。通过相关药物治疗,如黄体酮、地屈孕酮、人绒毛膜促性腺激素等,均可有效提高妊娠成功率,降低患者血清CA125水平。不同药物作用机制有所差异,临床可根据患者具体情况选择合适药物。但早期先兆流产与血清CA125之间的关系及作用机制尚无统一说法,CA125在早期先兆流产中的相关基础值及阈值变化亦不明确,有待进一步研究。

Research Progress on the Relationship between Early Threatened Abortion and Carbohydrate Antigen 125

The incidence of early threatened abortion is increasing,which is one of the major obstetric diseases of particular concern.It is important that obstetrician should focus on the monitoring and treatment of early threatened abortion.After reviewing literatures,we found that the important roles of carbo hydrate antigen125(CA125)in early threatened abortion have been raised more and more concern.Serum CA125 may be one of the predictors and diagnostic markers of early threatened abortion.Many drugs such as progesterone,didroxyprogesterone and human chorionic gonadotropin can effectively improve the pregnancy success rate and reduce the level of serum CA125.Based on different mechanism,these drugs can be tried in different patients.However,there is no unified statement on the relationship between early threatened abortion and serum CA125,and the related basic values and thresholds of CA125 in early threatened abortion are not clear.Relevant details need further study.