涤痰汤加减治疗冠心病心绞痛有效性及安全性的Meta分析

目的 评价涤痰汤加减治疗冠心病心绞痛的有效性及安全性.方法 计算机检索PubMed、Cochrance Library、EMbase、Mdeline、Sinomed、CNKI、Wanfang Data、VIP等数据库,纳入相关临床随机对照试验,采用RevMan软件分析数据.结果 纳入11篇文献,涉及患者1346例.主要...

Efficacy and safety of Ditan Decoction in the treatment of angina pectoris of coronary heart disease

Objective To evaluate the efficacy and safety of Ditan Decoction in the treatment of angina pectoris of Coronary Heart Dsease.Methods PubMed,Cochrane Library,EMBASE,mdeline,sinomed,CNKI,Wanfang Data,VIP and other databases were retrieved by computer and included in the related clinical randomized controlled trials.Revman software was used to analyze the data.Results 11 articles were included,involving 1346 patients.Main outcome measures were based on Seattle Angina scale.The experimental group was 2.05 lower than the control group.Secondary outcome indicators:①Grace Score:Compared with the control group,the average decrease in the experimental group was 1.23.②ECG:Compared with the control group,the effective rate of ECG improvement in the experimental group was about 1.23 higher than that in the control group.③TCM symptom effect:Compared with the control group,the experimental group has a 1.62-lower chest pain score,a 1.64-lower chest distress score,a 2.37-lower palpitation score,and a 3.69-lower body fatigue score.④Occurrence of adverse events:Due to the limitation of the number of studies included and adverse events reported,the safety of Ditan Decoction addition and subtraction still needed to be further verified by future clinical trials.Conclusion Ditan Decoction can improve angina pectoris,myocardial ischemia and the clinical prognosis,relieve the symptoms such as chest pain,chest distress,palpitation and physical sleepiness,and provide some reference for the clinical treatment of angina pectoris of coronary heart disease.