丙种球蛋白联合甲强龙冲击治疗 急性播散性脑脊髓炎患儿的疗效

目的:探讨丙种球蛋白联合甲强龙冲击治疗急性播散性脑脊髓炎患儿的临床疗效及副作用。方法:选取急性播散性脑脊髓炎患儿56例,随机分为单纯组与联合组各28例。2组均予甲强龙冲击治疗,联合组另给予丙种球蛋白。对比2组临床症状缓解时间,并比较治疗前、治疗1周、治疗1月的神经功能障碍量表(EDSS)评分及临床疗效,另观察药物副作用及后遗症情况。结果:联合组的临床症状恢复时间均短于单纯组(P0.05);2组治疗1周及治疗1月的EDSS评分均低于治疗前,2组治疗1月的EDSS评分均低于治疗1周,联合组治疗1周及治疗1月的EDSS评分均低于单纯组(P0.05);2组临床疗效等级分布比较差异具有统计学意义(P0.05),联合组总有效率高于单纯组(P0.05);2组总不良反应发生率及后遗症遗留率比较差异均无统计学意义(P0.05)。结论:丙种球蛋白联合甲强龙冲击治疗急性播散性脑脊髓炎患儿,可明显加快临床症状缓解,促进神经功能恢复,提高治疗效果,且安全性较好,并可在一定程度上减少后遗症。

Effect of Gamma Globulin Combined with Methylprednisolone Pulse Therapy in Children with Acute Disseminated Encephalomyelitis

To investigate the clinical efficacy and side effects of gamma globulin combined with methylprednisolone pulse therapy in the treatment of acute disseminated encephalomyelitis in children. Methods: Fifty-six children with acute disseminated encephalomyelitis were selected and randomly divided into the simple group and combined group with 28 cases in each group. The 2 groups were both treated with methylprednisolone pulse therapy while the combined group was additionally given gamma globulin. The recovery time of symptoms were compared between the 2 groups. The expanded disability status scale (EDSS) score before treatment, after 1 week of treatment, and after 1 month of treatment and clinical efficacy were compared, and drug side effects and sequelae were also monitored. Results: The recovery time of symptoms of the combined group were shorter than those of the simple group (P<0.05). The EDSS scores at 1 week and 1 month of treatment of both groups were lower than those before treatment, and the EDSS scores at 1 month of treatment of both groups were lower than those at 1 week of treatment; moreover, scores of the combined group at 1 week and 1 month of treatment were lower than those of the simple group (P<0.05). There was a significant difference in the clinical efficacy grade distribution between the 2 groups (P<0.05), and the total effective rate of the combined group was higher than that of the simple group (P<0.05). There was no significant difference in the incidence rates of total adverse reactions and the occurrence rates of sequelae between the 2 groups (P>0.05). Conclusion: Gamma globulin combined with methylprednisolone pulse therapy in the treatment of children with acute disseminated encephalomyelitis can significantly accelerate the relief of clinical symptoms, promote the recovery of nerve function, and improve therapeutic effect. Furthermore, it is relatively safe and can reduce sequelae to a certain extent.