术前血清CEA、CA19-9、CA50、AFP、TPS检测在结直肠癌肝转移中的预测价值

目的探讨在结直肠癌肝转移预测中,术前血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原50(CA50)、甲胎蛋白(AFP)、组织多肽特异性抗原(TPS)检测的应用价值。方法选取该院接诊的结直肠癌患者168例,根据术后病理结果,将发生肝转移的患者45例作为观察组,未转移患者123例作为对照组,对入组对象进行血清抽检,分析血清CEA、CA19-9、CA50、AFP、TPS表达。结果观察组血清CEA、CA19-9、CA50、AFP、TPS检测结果均高于对照组,差异有统计学意义(P<0.05);结直肠癌肝转移患者中,血清CEA、CA19-9在不同T分期患者所占百分比相比较,差异有统计学意义(P<0.05);血清指标单独检测阳性率与联合检测阳性率比较,差异有统计学意义(P<0.05);五项指标联用的灵敏度为84.44%,特异度为94.31%。结论在结直肠癌肝转移预测诊断中,术前血清CEA、CA19-9、CA50、AFP、TPS联合检测具有较高应用价值。

Preoperative detection of serum CEA,CA19-9,CA50,AFP and TPS in predicting liver metastasis of colorectal cancer

Objective To explore the value of serum carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 50(CA50),alpha fetoprotein(AFP)and tissue polypeptide specific antigen(TPS)in predicting liver metastasis of colorectal cancer.Methods 168 patients with colorectal cancer in our hospital were selected.According to the pathological results after operation,45 patients with liver metastasis were selected as the observation group and 123 patients without liver metastasis as the control group.Serum samples were taken to analyze the expression of serum CEA,CA19-9,CA50,AFP and TPS.Results The results of serum CEA,CA19-9,CA50,AFP and TPS in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05);The percentage of serum CEA and serum CA19-9 in patients with liver metastasis of colorectal cancer in different T stages were statistically significant,the difference was statistically significant(P<0.05);The positive rates of serum indicators were significantly different from those of combined detection,the difference was statistically significant(P<0.05).The sensitivity and specificity were 84.44%and 94.31%respectively.Conclusion Preoperative serum CEA,CA19-9,CA50,AFP and TPS combined detection have high value in predicting liver metastasis of colorectal cancer.