初诊系统性红斑狼疮患者血清OC、PINP、CTX、25-OH-VitD与狼疮活动度的相关性分析

目的检测初诊系统性红斑狼疮(SLE)患者血清中骨钙素(OC)、Ⅰ型原胶原分子N端前肽(PINP)、Ⅰ型胶原交联C-末端肽(CTX)、25羟基维生素D(25-OH-VitD)的水平,探讨骨代谢相关指标是否可以作为初诊SLE病情活动的监测指标。方法选择2017年7月1日至2019年1月1日在内蒙古自治区人民医院风湿免疫科住院的50例新发、初治的系统性红斑狼疮患者作为研究组,选择同时期于该院进行体检的健康志愿者35例作为对照组。检测研究组和对照组血清OC、PINP、CTX、25-OH-VitD及补体C3、C4水平,并对研究组SLE疾病活动指数(SLEDAI)积分进行评价。将OC、PINP、CTX、25-OH-VitD分别与补体C3、C4水平和SLEDAI积分进行相关性分析。结果研究组患者的血清OC和25-OH-VitD水平明显低于对照组,血清PINP和CTX水平明显高于对照组(P<0.05)。研究组患者血清补体C3和C4均显著低于对照组(P<0.05)。血清OC与补体C3呈正相关,与SLEDAI评分呈负相关(P<0.05)。血清PINP与SLEDAI评分呈正相关(P<0.05)。25-OH-VitD分别与补体C3、C4、SLEDAI评分呈负相关(P<0.05)。结论在初诊SLE患者血清中,OC、PINP、CTX、25-OH-VitD和补体C3、C4的水平均有显著变化,OC、PINP、CTX、25-OH-VitD可作为初诊SLE病情活动的监测指标。

Correlation analysis of serum OC,PINP,CTX,25-OH-VitD and lupus activity in patients with primary systemic lupus erythematosus

Objective To detect the levels of osteocalcin(OC),procollagen typeⅠN-terminal pro peptide(PINP),collagen typeⅠcross-linked C-terminal peptide(CTX)and 25-OH-VitD in the serum of patients with systemic lupus erythematosus(SLE)and to explore whether the related indexes of bone metabolism can be used as the monitoring indexes of SLE.Methods From July 1,2017 to January 1,2019,50 newly diagnosed and newly treated systemic lupus erythematosus patients in the Department of Rheumatology and Immunology,Inner Mongolia People′s Hospital were selected as the study group,and 35 healthy volunteers who were expected to have physical examination in the hospital at the same time were selected as the control group.The levels of serum OC,PINP,CTX,25-OH-VitD,complement C3 and C4 were measured in the study group and the control group,and the scores of SLE disease activity index(SLEDAI)in the study group were evaluated.The correlation of OC,PINP,CTX,25-OH-VitD with C3,C4 and SLEDAI was analyzed.Results The levels of serum OC and 25-OH-VitD in the study group were significantly lower than those in the control group,and the levels of serum PINP and CTX were significantly higher than those in the control group(P<0.05).The levels of C3 and C4 in the study group were significantly lower than those in the control group(P<0.05).Serum OC was positively correlated with complement C3 and negatively correlated with SLEDAI score(P<0.05).There was a positive correlation between serum PINP and SLEDAI score(P<0.05).25-OH-VitD was negatively correlated with C3,C4 and SLEDAI scores(P<0.05),respectively.Conclusion The serum levels of OC,PINP,CTX,25-OH-VitD,C3 and C4 were significantly changed in the newly diagnosed SLE patients.OC,PINP,CTX and 25-OH-VitD could be used as the monitoring indexes of SLE activity.