| 血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂在新型冠状病毒肺炎疫情防控中的应用分析 |
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| 引用本文： | 吴瑶,余珊,段杰,王芊入,吴倪,李波,姜黎.血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂在新型冠状病毒肺炎疫情防控中的应用分析[J].实用药物与临床,2021,24(1):1-5. |
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| 作者姓名： | 吴瑶 余珊 段杰 王芊入 吴倪 李波 姜黎 |
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| 作者单位： | 成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730;成都市郫都区人民医院药学部,四川 成都611730 |
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| 基金项目： | 四川医事卫生法治研究中心资助项目(YF19-Q14);成都市郫都区人民医院新型冠状病毒肺炎院内课题(2020XG01)。 |
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| 摘 要： | 根据《中国心血管病报告》,中国现患心血管病人数约2.9亿,而大量循证医学证据证实了血管紧张素转换酶抑制剂(ACEI)或血管紧张素受体拮抗剂(ARB)治疗心血管等疾病的价值.ACEI/ARB是肾素-血管紧张素-醛固酮系统(RAAS)的阻滞剂,可上调血管紧张素转换酶2(ACE2)表达水平.而ACE2是新型冠状病毒肺炎(CO...
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| 关 键 词： | 新型冠状病毒肺炎 新型冠状病毒 血管紧张素转化酶2 血管紧张素转换酶抑制剂 血管紧张素受体拮抗剂 心血管疾病 肾素-血管紧张素-醛固酮系统 |
Application of angiotensin-converting enzyme inhibitor/angiotensin receptor antagonist during COVID-19 epidemic prevention and control |
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| WU Yao,YU Shan,DUAN Jie,WANG Qian-ru,WU Ni,LI Bo,JIANG Li.Application of angiotensin-converting enzyme inhibitor/angiotensin receptor antagonist during COVID-19 epidemic prevention and control[J].Practical Pharmacy and Clinical Remedies,2021,24(1):1-5. |
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| Authors: | WU Yao YU Shan DUAN Jie WANG Qian-ru WU Ni LI Bo JIANG Li |
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| Institution: | (Department of Pharmacy,Pidu District People′s Hospital,Chengdu 611730,China) |
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| Abstract: | According to the Chinese Cardiovascular Disease Report,there are about 290 million people with cardiovascular diseases in China,and a large amount of evidence-based medical evidence has shown the value of angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor antagonist(ARB)in the treatment of cardiovascular diseases.ACEI/ARB is a blocking agent of renin-angiotensin-aldosterone system(RAAS),which can up-regulate the expression level of angiotensin-converting enzyme 2(ACE2).ACE2 is a key molecular target for the development of Corona Virus Disease 2019(COVID-19).On the one hand,ACE2 is an essential receptor for the invasion of human cells,triggering the development of COVID-19,and on the other hand,it plays an anti-inflammatory protective role in the development of COVID-19.In this paper,we discuss whether ACEI/ARB can be used during COVID-19 epidemic prevention and control,so as to provide ideas and references for the rational use of ACEI/ARB in patients with cardiovascular diseases. |
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| Keywords: | Corona Virus Disease 2019 Novel coronavirus Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitor Angiotensin receptor antagonist Cardiovascular disease Renin angiotensin-aldosterone system |
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