自贡地区1665例女性抗缪勒氏管激素水平与年龄的相关性分析

目的分析自贡地区女性抗缪勒氏管激素(AMH)的变化与年龄的关系。方法以自贡市妇幼保健院生殖医学中心就诊的1665例20~50岁女性为研究对象,按照年龄分为4组,回顾分析血清中AMH的变化,比较各年龄组中血清AMH水平与年龄的关系。结果20~25岁、>25~30岁、>30~35岁、>35~40岁组中血清AMH水平依次降低且差异均有统计学意义(P<0.01)。AMH水平与年龄呈负相关,且二者关系为Y=12.328-0.261 X(r^2=0.255)。不孕患者血清AMH水平部分异常。结论伴随年龄的增长,孕龄期女性体内AMH水平逐渐降低。发现AHM的水平和不孕的发病率有关系,但不能作为诊断不孕的指标,可为后期研究血清AHM与不孕症的关系提供思路。

Anti-Mullerian hormone test and age analysis for 1665 females in Zigong Area

Objective To analyzed the relationship between the level of anti-Mullerian hormone(AMH)and age in women.Methods A total of 1665 women aged 20-50 who were admitted to the Reproductive Medicine Center of the Maternal and Child Health Hospital of Zigong City were selected as the subjects of the study and were divided into 4 groups according to age.The levels of serum AMH were retrospectively analyzed between the 4 groups,and the relationship between serum AMH level and age in each group was compared.Results Serum AMH levels showed a decreasing trend in the 20-25,>25-30,>30-35,and>35-40 age groups,with statistically significant differences(P<0.01).AMH levels were negatively correlated with age,and the correlation was Y=12.328-0.261 X(r^2=0.255).The serum AMH levels were abnormal in infertile patients.Conclusion With the increase of age,the AMH level gradually decreased in childbearing women.This study showed that the level of AMH was related to the incidence of infertility,but it cannot be used as a measure for the diagnosis of infertility,which indicates some clues for the study between serum AHM and infertility.