血清PTX3和Gal-3在高血压合并冠状动脉粥样硬化性心脏病患者中的水平变化及其临床意义

目的探讨血清五聚素3(PTX3)、半乳糖凝集素3(Gal-3)水平在高血压合并冠状动脉粥样硬化性心脏病(CHD)患者中的变化及临床意义。方法选取该院2017年2月至2019年2月所接诊的60例单纯高血压患者(单纯高血压组)、60例高血压合并CHD患者(高血压合并CHD组)及50例健康者(对照组)纳入研究,比较三组的临床资料及血清PTX3、Gal-3水平,并比较不同病变血管数的高血压合并CHD患者血清PTX3、Gal-3水平的差异。结果高血压合并CHD组高血压病程、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平明显长于或高于单纯高血压组,高密度脂蛋白胆固醇(HDL-C)水平明显低于单纯高血压组(P<0.05);高血压合并CHD组血清PTX3、Gal-3水平明显高于单纯高血压组和对照组,单纯高血压组血清PTX3、Gal-3水平明显高于对照组(P<0.05);多支病变组血清PTX3、Gal-3水平明显高于双支病变组、单支病变组,双支病变组血清PTX3、Gal-3水平明显高于单支病变组(P<0.05);多因素logistic回归模型中显示,高血压病程,TC、LDL-C、PTX3、Gal-3水平和CHD的发生风险呈正相关,与HDL-C水平呈负相关(P<0.05)。结论血清PTX3、Gal-3水平在高血压合并CHD患者中明显升高,而且随着病变血管支数的增加而升高,可通过加重血管炎症的途径,进一步增加心肌损伤程度,该研究也为临床防治高血压合并CHD提供了新思路。

The concentration change and clinical significance of serum PTX3 and Gal-3 levels in patients with hypertension and coronary heart disease

Objective To study the the concentration change and and clinical significance of serum plasma pentamer 3(PTX3)and galactose agglutinin-3(Gal-3)in patients with hypertension and coronary heart disease.Methods A total of 60 cases of simple hypertension,60 cases of hypertension with coronary heart disease and 50 cases of healthy persons(control group)received in our hospital from February 2017 to February 2019 were included in the study,the clinical data and the expression of serum PTX3 and Gal-3 concentration in the three groups were compared,and the expression of serum PTX3 and Gal-3 concentration in the hypertension and coronary heart disease with difference lesions number were compared.Results The hypertension course,total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)in hypertension with coronary heart disease group were significantly higher than those in simple hypertension group,and the high density lipoprotein cholesterol(HDL-C)were significantly lower than those in simple hypertension group(P<0.05);the serum PTX3 and Gal-3 concentration in hypertension with coronary heart disease group were significantly higher than those in simple hypertension group and control group,and the serum PTX3 and Gal-3 in the simple hypertension group were significantly higher than those in control group(P<0.05);the serum PTX3 and Gal-3 concentration in multi-vessel lesion group were significantly higher than those in double-vessel lesion and single-vessel lesion group,and the serum PTX3 and Gal-3 concentration in double-vessel lesion group were significantly higher than those in single-vessel lesion group(P<0.05);in the multivariate logistic regression model showed that the hypertension duration,TC,LDL-C,PTX3,Gal-3 concentration and the risk of coronary heart disease positively correlated,while HDL-C negatively correlated(P<0.05).Conclusion The serum PTX3 and Gal-3 concentration increased significantly in patients with hypertension and coronary heart disease,and increased with the increase of the number of lesion branches,which can further increase the degree of myocardial injury by aggravating vascular inflammation,and this study also provides a new idea for clinical prevention and treatment of hypertension with coronary heart disease.