慢性自发性荨麻疹患者血清维生素D、脱氢表雄酮硫酸酯水平与Th1/Th2细胞因子及免疫球蛋白的关系分析

目的探讨不同程度慢性自发性荨麻疹(CSU)患者血清维生素D、脱氢表雄酮硫酸酯(DHEA-S)水平与辅助性T(Th)1/Th2细胞因子、免疫球蛋白的关系及临床意义。方法选取北京京城皮肤医院2016年1月至2017年12月收治的137例CSU患者作为观察组,依据CSU病情分级将观察组分为轻度组(59例)、中度组(41例)、重度组(37例),选取同期该院体检健康者70例作为对照组。比较观察组与对照组、不同CSU病情分级患者血清25-羟基维生素D25(OH)D]、DHEA-S、Th1/Th2细胞因子、免疫球蛋白水平。结果与对照组比较,观察组血清25(OH)D、DHEA-S、白细胞介素(IL)-2、干扰素(IFN)-γ水平较低,血清IL-4、免疫球蛋白(Ig)E、IgG水平较高(P<0.05)。轻、中、重度组血清25(OH)D、IL-2、IL-4、IFN-γ水平整体比较,差异无统计学意义(P>0.05);病情越重,血清DHEA-S水平越低,IgE、IgG水平越高(P<0.05)。CSU患者血清25(OH)D与IL-2水平呈正相关,与IL-4、IFN-γ水平呈负相关(P<0.05);CSU患者血清DHEA-S与IL-2、IFN-γ水平呈正相关,与IL-4、IgE水平呈负相关(P<0.05)。结论CSU患者血清维生素D水平的降低可能与Th1/Th2细胞失衡相关,血清DHEA-S水平的降低则可能与Th1/Th2细胞失衡及病情的进展相关,也可能与IgE介导的Ⅰ型变态反应相关。

Analysis of the relationship between serum vitamin D and dehydroepiandrosterone sulfate levels with Th1/Th2 cytokines and immunoglobulins in patients with chronic spontaneous urticaria

Objective To investigate the relationship between serum vitamin D and dehydroepiandrosterone sulfate(DHEA-S)levels and Th1/Th2 cytokines and immunoglobulins in patients with chronic spontaneous urticaria(CSU)and their clinical significance.Methods A total of 137 CSU patients admitted from January2016 to December 2017 in Beijing Jingcheng Skin Hospital were selected as the observation group.The observation group was divided into mild group(59 cases),moderate group(41 cases),and severe group(37 cases)according to the CSU disease classification,70 cases of healthy people in the hospital during the same period were selected as the control group.Compare the levels of serum 25-hydroxyvitamin D25(OH)D],DHEA-S,Th1/Th2 cytokines,and immunoglobulin in the observation group with the control group and patients with different CSU conditions.Results Compared with the control group,the serum 25(OH)D,DHEA-S,interleukin(IL)-2,and interferon(IFN)-γlevels were lower in the observation group,and serum IL-4,immunoglobulin(Ig)E,and IgG levels were higher(P<0.05).There was no significant difference in the overall levels of serum 25(OH)D,IL-2,IL-4,and IFN-γin the mild,moderate,and severe groups(P>0.05);the more severe the disease,the lower the serum DHEA-S level,and the higher the IgE and IgG levels(P<0.05).Serum 25(OH)D was positively correlated with IL-2 level in CSU patients,and negatively correlated with IL-4 and IFN-γlevels(P<0.05).Serum DHEA-S was positively correlated with IL-2 and IFN-γlevels in CSU patients,and negatively correlated with IL-4 and IgE levels(P<0.05).Conclusion The decrease in serum vitamin D level in CSU patients may be related to the imbalance of Th1/Th2 cells,and the decrease in serum DHEA-S level may be related to the imbalance of Th1/Th2 cells and the progression of the disease,and may be related to IgE-mediated typeⅠallergies.