| 国产吉西他滨联合顺铂治疗晚期非小细胞肺癌 |
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| 引用本文： | 张毅,胡庆丰,吴一萍.国产吉西他滨联合顺铂治疗晚期非小细胞肺癌[J].实用全科医学,2008,6(9):897-898. |
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| 作者姓名： | 张毅 胡庆丰 吴一萍 |
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| 作者单位： | 皖南医学院第二附属医院肿瘤科,安徽省芜湖市241000 |
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| 摘 要： | 目的评价国产吉西他滨（GEM）联合顺铂（DDP）治疗晚期非小细胞肺癌（NSCLC）的近期疗效和不良反应。方法27例晚期非小细胞肺癌患者应用择菲联合顺铂化疗，吉西他滨1000mg／m2第1天、第8天，顺铂20mg／m2第1-4天，21d为1个周期，2～3个周期后评价疗效和不良反应。结果总有效率（CR＋PR）为40．7％，不良反应为骨髓抑制和胃肠道反应。结论国产吉西他滨联合顺铂治疗晚期非小细胞肺癌疗效较好，不良反应轻。
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| 关 键 词： | 非小细胞肺肿瘤 吉西他滨 顺铂 联合化疗 |
Combination of Gemcitabine and Cisplatin for Patients with Advanced Non-small-cell Lung Cancer |
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| ZHANG Yi,HU Qing-feng,WU Yi-ping.Combination of Gemcitabine and Cisplatin for Patients with Advanced Non-small-cell Lung Cancer[J].Applied Journal Of General Practice,2008,6(9):897-898. |
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| Authors: | ZHANG Yi HU Qing-feng WU Yi-ping |
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| Institution: | ( Department of Oncology,the Second Affiliated Hospital of Wannan Medical College,Anhui 241000,China ) |
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| Abstract: | Objective To evaluate the curative effect and adverse reactions of combination of gemcitabine and cisplatin for pa- tients with advanced non-small-cell lung cancer （NSCLC）. Methods 27 patients with advance NSCLC were treated with this chemotherapy regimen. 1 000 mg/m2 gemcitabine was given at 1st and 8th day and 20 mg/m2 Cisplatin were given from 1st to 4th days. The chemotherapy was repeated every 21 days on two or three cycles. Results Among these 27 patients, the overall re- sponse rate（ CR ＋ PR） was dO. 7%. The main adverse reactions were myelosuppression, nausea and vomiting. Conclusions Gemcitabine combined with Cisplatin is an effective treatment for patients with advance NSCLC and adverse reactions is accepta- ble. |
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| Keywords: | NSCLC Gemcitabine Cisplatin Combination Chemotherapy |
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