Characteristics of N400 component elicited in patients who have migraine with aura |
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| Authors: | Igor Petrusic Vojislav Jovanovic Vanja Kovic Andrej Savic |
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| Institution: | 1.Laboratory for Advanced Analysis of Neuroimages, Faculty of Physical Chemistry, University of Belgrade, 12-16 Studentski Trg Street, Belgrade, 11000 Serbia ;2.Laboratory for Neurocognition and Applied Cognition, Department of Psychology, Faculty of Philosophy, University of Belgrade, Belgrade, Serbia ;3.Science and Research Centre, School of Electrical Engineering, University of Belgrade, Belgrade, Serbia |
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| Abstract: | BackgroundThis study aimed to examine the N400 effect and event-related potentials (ERPs) elicited from congruent and incongruent stimuli in patients who have migraines with aura (MwA).MethodsA total of 33 MwA patients and 20 healthy controls (HCs) were studied. They were balanced in age (35.12 ± 8.94 vs 34.70 ± 9.59 years, p = 0.872) and sex (69.7 vs 75.0% females, p = 0.761). ERPs were measured in response to both stimuli, where pictures were preceded with an object name that either matched or mismatched with the object. Averaged amplitudes, peaks, peak latencies, difference waves and topography were compared between MwA and HCs.ResultsMwA patients had significantly lower averaged amplitudes at the Fz and F4 sites during incongruent stimuli, as well as reduced peaks at the C3 and Pz sites. Topography showed a more widespread N400 effect over scalp relative to HCs. The difference ERP waveforms did not differ in the N400 effect between groups, but the P600 effect was significantly stronger in the HCs group relative to the MwA group at the Pz (6.52 ± 2.57 vs. 3.50 ± 3.15, p = 0.001) and P4 (5.86 ± 2.79 vs. 3.95 ± 3.64, p = 0.040) sites.ConclusionsPicture-word matching tasks could serve as a potential new method for the investigation of semantic processing in MwA patients. |
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| Keywords: | Electroencephalography Event-related potentials Headache Semantic processing Source localization |
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