| 抗T淋巴细胞单克隆抗体治疗骨髓增生异常综合征 |
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| 引用本文： | 王鲁群,迟翠芳,孔凡盛,黄宁,刘希民,李嵋,张东红,周兰月,张明珙,宋素芹. 抗T淋巴细胞单克隆抗体治疗骨髓增生异常综合征[J]. 中国肿瘤生物治疗杂志, 1996, 3(2): 124-126 |
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| 作者姓名： | 王鲁群 迟翠芳 孔凡盛 黄宁 刘希民 李嵋 张东红 周兰月 张明珙 宋素芹 |
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| 作者单位： | 济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031，济南军区总医院血液科!济南250031 |
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| 摘 要： | 用抗T淋巴细胞单克隆抗体SMU3(抗CD3)和SMU8(抗CD8)治疗10例骨髓增生异常综合征(MDS),结果表明:2例明显进步,5例进步,白细胞和血红蛋白显著升高。治疗前CD4~ 细胞少,CD8~ 细胞多,CD4/CD8比值降低或倒置,HLA-DR抗原高表达,与对照组比较均有显著差异,治疗后T淋巴细胞亚群比例恢复,HLA-DR表达降低。T淋巴细胞各亚群比例失调和功能异常是MDS的诱发因素之一。
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| 关 键 词： | 单克隆抗体 T淋巴细胞 骨髓增生异常综合征 |
| 收稿时间： | 1995-12-14 |
| 修稿时间： | 1996-03-04 |
Treatment of Myelodysplastic Syndrome with Monoclonal Anti-Human T Lymphocyte Antibody |
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| Wang Luqun,Chi Cuifang,Kong Fansheng,Huang Ning,Liu Ximin,Li Mei,Zhang Donghong,Zhou Yuelan,Zhang Minghong and Song Suqin. Treatment of Myelodysplastic Syndrome with Monoclonal Anti-Human T Lymphocyte Antibody[J]. Chinses Journal of Cancer Biotherapy, 1996, 3(2): 124-126 |
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| Authors: | Wang Luqun Chi Cuifang Kong Fansheng Huang Ning Liu Ximin Li Mei Zhang Donghong Zhou Yuelan Zhang Minghong Song Suqin |
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| Affiliation: | Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031;Department of Hematology, Jinan General Hospital of PLA Jinan 250031 |
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| Abstract: | Ten patients with myelodysplastic syndrome (MDS) were treated with monoclonal anti -human T lymphocyte antibodies SMU3 (anti - CD3) and SMU8 (anti - CD8) . The results suggested that two patients got a significant progress and five patients turned better. Before treatment the patients had less CD4 cells, more CD8 cells, lower or inverted ratio of CD4/ CD8, higher expression of HLA -DR antigen than normal control and these differences were significant. After treatment T lymphocyte subsets and HLA - DR expression turned normal. T lymphocyte subsets imbalance and abnormal function in patients is one of the factors which induced MDS. |
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| Keywords: | monoclonal antibody T lymphocyte myelodysplastic syndrome |
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