| 联合应用成纤维细胞介导的G-CSF基因疗法及IL-2基因疗法对肿瘤的治疗作用 |
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| 引用本文： | 于益芝,曹雪涛,雷虹,董虹,章卫平.联合应用成纤维细胞介导的G-CSF基因疗法及IL-2基因疗法对肿瘤的治疗作用[J].中国肿瘤生物治疗杂志,1996,3(1):38-64. |
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| 作者姓名： | 于益芝 曹雪涛 雷虹 董虹 章卫平 |
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| 作者单位： | 第二军医大学免疫学教研室!上海200433 |
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| 基金项目： | 上海市科技启明星培养计划，国家自然科学基金，优秀中青年人才专项基金(39421009)资助 |
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| 摘 要： | 本实验观察了成纤维细胞介导的G-CSF基因疗法对大剂量化疗后造血功能损伤小鼠的恢复作用。结果发现:接受G-CSF基因治疗的实验小鼠外周血白细胞尤其是中性粒细胞降低程度明显减弱,恢复速度明显加快;并可明显促进血小板的恢复,但作用较缓;其脾脏和骨髓CFU-GM、CFU-MK、CFU-S水平显著地高于对照组,表明成纤维细胞介导的G-CSF基因疗法可显著降低大剂量化疗后造血损伤程度,并明显加速受损的造血功能的恢复。
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| 关 键 词： | 粒细胞集落刺激因子 基因治疗 成纤维细胞 化疗 造血恢复 |
| 收稿时间： | 1995/10/8 0:00:00 |
The Therapeutic Effects Of Combined Fibroblast-Mediated IL-2 and G-CSF Gene Therapy on Tumor-Bearing Mice |
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| Yu Yizhi,Cao Xuetao,Lei Hong,Dong Hong and Zhang Weiping.The Therapeutic Effects Of Combined Fibroblast-Mediated IL-2 and G-CSF Gene Therapy on Tumor-Bearing Mice[J].Chinese Journal of Cancer Biotherapy,1996,3(1):38-64. |
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| Authors: | Yu Yizhi Cao Xuetao Lei Hong Dong Hong and Zhang Weiping |
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| Institution: | Department of Immunology, Second Military Medical University, Shanghai 200433;Department of Immunology, Second Military Medical University, Shanghai 200433;Department of Immunology, Second Military Medical University, Shanghai 200433;Department of Immunology, Second Military Medical University, Shanghai 200433;Department of Immunology, Second Military Medical University, Shanghai 200433 |
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| Abstract: | In the present study, the effects of G-CSF gene therapy was investigated on the recovery of murine hematopoietic suppression induced by high dose of cyclophosphomide (Cy) . The results showed that G-CSF gene therapy could slow down the Cy-induced decreasing of peripheral WBCs and platelets, and accerelate their recovery.It also could increase the CFU-GM, CFU - MK, CFU-S derived from the splenocyte and bone marrow cells in the chemotherapy-treated mice. The data demonstrated that fibroblast-mediated G-CSF gene therapy could significantlyreduce the hematopoietic damage to less extent, and accerelate hematopoietic recovery after chemotherapy. |
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| Keywords: | granulocyte colony - stimulating factor gene therapy fibroblast chemotherapy hematopoietic recovery |
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