Chemiluminescence study of the contents of the products of Cu2+-induced lipid peroxidation in different fractions of human blood lipoproteins |
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Authors: | E S Dremina T V Vakhrusheva V S Sharov O A Azizova Yu A Vladimirov |
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Institution: | (1) Department of Biophysics, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow |
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Abstract: | It is demonstrated that the content of the primary products of lipid peroxidation reaches the maximum after about 1-h incubation
with Cu2+ and then declines. At a Cu2+ concentration of about 10–15 μM, the content of lipid peroxidation products is maximal; it does not rise with a further increase
in the Cu2+ concentration. Comparison of the kinetics of lipid peroxidation in different lipoprotein fractions shows that low density
lipoproteins are much more strongly oxidized than high density lipoproteins. A strong positive correlation between the amplitude
of the chemiluminescence burst and the diene conjugate content is established in 79 independent measurements.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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2, pp. 144–148, February, 1995 |
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Keywords: | lipoproteins chemiluminescence copper ions lipid peroxidation |
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