血液动力学方法治疗犬脑血管痉挛的实验研究

采用不同的血液动力学方法，对犬网膜下腔出血后引起的症状性脑血管痉挛进行治疗，我们发现：（１）等容称释加胞二磷胆碱和多巴酚丁胺疗法与人工扩容疗法疗效相同，但与等容稀释加胞二磷胆碱疗法相比，疗效有显著性差异，前者尤其知于扩容稀释禁忌证的病人；（２）稀释剂中加入胞二磷胆碱，可使红细胞变形能力半加，改善脑微循环（３）大剂量应用多巴胺升压，部分病例可使ＣＶＳ加重，临床应慎用。

Study on Symptomatic Vasospasm Treated with Different Hemodynamic Methods in Dogs

In present study,the animal models induced by symptomatic vasospasm were treated with different hemodynamic methods.25 dogs were divided randomly into 5 groups:A:control group;B:hypervolemic hemodilution group;C:B+CDPC;D:isovolemic hemodilution+CDPC;E:D+dobutamine.The results show as follows:(1) There is no difference of therapeutic effect between E and B groups,but there is significant difference between D and E groups.(2) CDPC can increase erythrocyte deformability,so, it improves the brain microcirculation.(3)It may be dangerous if induced hypertension with high dose of dopamine.