PTEN在大肠癌癌变过程中的表达及意义

目的探讨在大肠癌癌变过程中，即大肠正常组织、大肠增生性息肉、大肠腺瘤和大肠癌中PTEN的表达及意义。方法应用免疫组织化学SP法检测122例大肠组织标本中PTEN蛋白的表达，应用等级相关的秩和检验分析PTEN在大肠组织中表达的意义及其与临床病理特征间的关系。结果PTEN蛋白在正常大肠组织、大肠增生性息肉、大肠腺瘤、大肠癌中表达差异有明显统计学意义（P=0．000）。大肠癌中PTEN蛋白表达与肿瘤分化程度、临床肿瘤分期及性别无关（P〉0．05），但与患者的年龄相关（P=0．002）。结论PTEN蛋白在大肠癌癌变过程中存在异常表达，PTEN蛋白的低表达与大肠癌的发生和浸润转移相关。

The expression and significance of PTEN in progression of colorectal cancer

Objective To explore the expression and significance of PTEN in the progression of colorectal cancer, including normal colorectal tissue, colorectal hyperplastic polyps, colorectal adenoma and colorectal cancer. Methods The expression of PTEN was detected in 122 specimens using immunohistochemistry （SP method）. The relationship between the expression of PTEN protein and clinicopathological factors was analyzed by Kruskal-Wallis test. Results There was significant diffierence of the expression of PTEN protein among normal colorectal tissue, colorectal hyperplastic polyps, colorectal adenoma and colorectal cancer （P = 0. 000）. No positive correlation was found in colorectal cancer between the expression of PTEN and degree of differentiation, Dukes＇ stage, or genger （P 〉 0.05 ）. But there was a positive correlation between its expression and the patient＇ s age （P = 0. 002）. Conclusion There was abnormal expression of PTEN protein in the progression of colorectal cancer. And its low expression was high related with the development, invasion and metastasis of colorectal cancer.