Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer |
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| Authors: | Van den Eynden G G Van der Auwera I Van Laere S J Huygelen V Colpaert C G van Dam P Dirix L Y Vermeulen P B Van Marck E A |
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| Affiliation: | Translational Cancer Research Group Antwerp (Lab Pathology University Antwerp/University Hospital Antwerp, Edegem; Oncology Center, General Hospital St-Augustinus, Wilrijk), Antwerp, Belgium. |
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| Abstract: | We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular. |
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| Keywords: | lymphangiogenesis lymph node metastases podoplanin D2-40 breast cancer |
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