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Self-administration of intravenous amphetamine: effect of nucleus accumbens CCKB receptor activation on fixed-ratio responding |
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| Authors: | D. E. A. Bush N. J. DeSousa F. J. Vaccarino |
| Affiliation: | (1) Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3, CA;(2) Departments of Psychiatry and Psychology, University of Toronto, Centre for Addiction and Mental Health, Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8 e-mail: Franco_Vaccarino@camh.net, Fax: +1-416-979-4695, CA |
| Abstract: | Rationale: The mesolimbic dopamine (DA) system is implicated in psychostimulant drug self-administration. The neuropeptide cholecystokinin (CCK) is co-localised with DA and inhibits nucleus accumbens (NAcc) DAergic neurotransmission via CCKB receptors. Objectives: The present experiment was designed to examine the effects of intra-NAcc CCKB receptor stimulation on fixed-ratio (FR) amphetamine self-administration. Methods: Wistar rats with intravenous catheters and NAcc cannulae were trained to self-administer amphetamine under a FR3 schedule of reinforcement. Animals performing stable self-administration were microinjected with pentagastrin and assessed during 3-h sessions. Results: Intra-NAcc pentagastrin dose dependently increased amphetamine intake. Conclusions: These results are consistent with the notion that NAcc CCKB receptor activation attenuates amphetamine reward. Received: 6 May 1999 / Final version: 4 August 1999 |
| Keywords: | Cholecystokinin CCKB receptor Amphetamine Self-administration Reinforcement Dopamine |
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