Novel therapies for chronic lymphocytic leukemia |
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Authors: | Mavromatis Blanche H Cheson Bruce D |
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Institution: | Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. |
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Abstract: | New therapies for chronic lymphocytic leukemia (CLL) are moving away from non-specific cytotoxic to more targeted approaches. The monoclonal antibody alemtuzumab induces responses in 33% to 43% of patients with relapsed or refractory disease, with 2-5% CR. Side effects include infusional reactions as well as immunosuppressive effects. Rituximab has limited activity in relapsed refractory patients, but response rates are comparable to follicular non-Hodgkin's lymphoma in untreated patients. Other antibodies in early phases of development include anti-CD23 IDEC-152], anti-CD22 epratuzumab], Hu1D10 apolizumab], and anti-CD80 anti-B7, IDEC-114]. Other agents that are being studied include denileukin diftitox fusion protein (Ontak), and bcl-2 antisense G3139, Genasense]. The mechanism of action of the new drugs and their role in CLL, as well as the emergence of new prognostic markers are discussed. |
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