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Congenital diaphragmatic hernia: new models,new ideas |
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| Authors: | A E Brandsma R Tenbrinck H Ijsselstijn E C Scheffers J L J Gaillard D Kluth A A W ten Have-Opbroek B Lachmann D Tibboel |
| Institution: | (1) Department of Pediatric Surgery, Sophia Children's Hospital, Dr. Molewaterplein 60, NL-3015 GJ Rotterdam, The Netherlands;(2) Department of Pulmonology, State University Leiden, The Netherlands;(3) Department of Pathology, Erasmus University Rotterdam, The Netherlands;(4) Department of Experimental Anesthesiology, Erasmus University Rotterdam, The Netherlands;(5) Department of Pediatric Surgery, Universität Kinderklinik, Hamburg, Germany |
| Abstract: | An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic studies to evaluate the presence of pulmonary hypoplasia and a closing defect of the diaphragm. Functional studies revealed abnormal surfactant levels and differences in pressure/volume curves following birth and during artificial ventilation for 6 h together with a disturbed antioxidant enzyme response. This animal model opens up new ways of studying the effects of prenatal hormonal modulation (corticosteroids, thyrotrophin-releasing hormone) on lung development as a novel therapeutic modality. |
| Keywords: | Congenital diaphragmatic hernia Lung development Pulmonary hypoplasia Pathogenesis Animal model |
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