脊髓髓内胶质瘤显微手术切除及survivin因子表达

目的 探讨脊髓髓内胶质瘤显微手术的临床效果及survivin因子在脊髓髓内胶质瘤组织中的表达及其临床意义。方法 采用显微外科技术切除髓内胶质瘤17例，其中室管膜瘤8例，星形细胞瘤9例。术后进行临床随访并定期复查MRI。运用免疫组织化学技术(SP法)检测髓内胶质瘤组织survivin因子表达。结果 髓内室管膜瘤8例，肿瘤全切除7例，次全切除1例。星形细胞瘤9例，肿瘤全切除3例，次全切除5例，部分切除1例。在8例室管膜瘤组织中的survivin因子阳性表达有2例，9例星形细胞瘤组织中survivin因子阳性表达有6例，其中2例中度阳性表达的患者随访均出现肿瘤颅内及椎管内播散种植。结论 髓内胶质瘤中室管膜瘤显微手术疗效满意。髓内星形细胞瘤组织survivin因子表达明显高于室管膜瘤，survivin中度阳性表达可能与肿瘤蛛网膜下腔播散种植有关。

Microsurgical treatment and survivin expression for intramedullary gliomas

Objective To detect the expression of survivin protein in intramedullary gliomas and evaluated the clinical significance of the survivin expression. Method Seventeen cases of intramedullary gliomas were removed by using microsurgical technique.It composed of 8 cases of ependymomas and 9 ones of astrocytomas.The patients were followed up by MRI scanning periodically.The survivin protein expression of the intramedullary gliomas were examined by immunohistochemical stain (SP). Results Total resection of the tumor was obtained in 7 cases of ependymomas and subtotal resection was undertaken in the other one case.For 9 cases of astrocytomas,total resection of the tumor achieved in 3 cases,subtoal resection in 5 cases and partial resection in one case.Survivin expression was detected in 2 samples of ependymomas and 6 ones of astrocytomas.2 astrocytoma cases were moderate positive staining,who suffering from intracranial and vertebral subarachnoid dissemination of the tumor. Conclusion The result of microsurgical treatment for intramedullary ependymomas is satisfactory.The survivin expression in astrocytoma samples is significantly higher than that in ependymoma.Moderate positive staining may correlated with subarachnoid dissemination of the tumor.