| 咬合力丧失影响大鼠牙周组织中白细胞介素-6mRNA表达的研究 |
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| 引用本文： | 袁林,赵云凤,周伟东. 咬合力丧失影响大鼠牙周组织中白细胞介素-6mRNA表达的研究[J]. 华西口腔医学杂志, 2001, 19(3): 0-154 |
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| 作者姓名： | 袁林 赵云凤 周伟东 |
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| 作者单位： | 1. 四川大学华西口腔医学院,
2. 第一军医大学珠江医院 |
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| 摘 要： | 目的：初探IL－6 mRNA在牙周组织改建中的分子机理，方法：选用Wistar大鼠建立正常咬合力，咬合力丧失的动物模型，采用原位杂交方法，观察牙周细胞中IL－6mRNA表达的动态变化，结果：咬合力丧失引起牙周细胞中IL－6mRNA表达较正常咬合力时明显增强。结论：咬合力失，促使IL－6 mRNA明显增多，诱发了破骨过程，影响着牙周组织的改建。
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| 关 键 词： | 咬合力 白细胞介素-6mRNA 牙周组织改建 原位杂交 |
| 收稿时间： | 2001-06-25 |
| 修稿时间： | 1999-10-15 |
Effects of Bite Force Loss on the Expression of IL-6 Mrna in Rat Periodontium |
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| Yuan Lin,Zhao Yunfeng,Zhou Weidong The College of Stomatology,West China University of Medical Sciences. Effects of Bite Force Loss on the Expression of IL-6 Mrna in Rat Periodontium[J]. West China journal of stomatology, 2001, 19(3): 0-154 |
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| Authors: | Yuan Lin Zhao Yunfeng Zhou Weidong The College of Stomatology West China University of Medical Sciences |
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| Affiliation: | College of Stomatology, West China University of Medical Sciences. |
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| Abstract: | Objective:The aim of this study is to evaluate the expression of IL_6 mRNA in rat periodontal cells under normal bite force and without bite force, and to explain periodontal remodeling from the molecular level. Methods:Animal models with normal bite force and without bite force were established by using Wistar rats. In situ hybridization technique was applied to detect changes of IL_6 mRNA expression in rat periodontal tissue. Results:Without bite force, the expression level of IL_6 mRNA increased significantly in periodontal cells. Conclusion:This study initially investigates the molecular mechanism of periodontal remodeling, and suggests that the histological morphology may be closely related to the mechanical stimulation. |
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| Keywords: | bite force IL_6 mRNA periodontium remodeling in situ hybridization |
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