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Immunogenicity of a Monovalent Pandemic Influenza A H1N1 Virus Vaccine with or without Prior Seasonal Influenza Vaccine Administration |
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| Authors: | Hidetoshi Igari Akira Watanabe Shunsuke Segawa Akiko Suzuki Mariko Watanabe Takayuki Sakurai Masaharu Watanabe Koichiro Tatsumi Mikio Nakayama Kazuo Suzuki Takeyuki Sato |
| Affiliation: | aDivisions of Control and Treatment of Infectious Diseases;bLaboratory Medicine, Chiba University Hospital, Chiba, Japan;cGraduate School of Nursing, Chiba University, Chiba, Japan;dDepartments of Respirology;fImmunology, Graduate School of Medicine, Chiba University, Chiba, Japan;eNational Institute of Infectious Diseases, Tokyo, Japan |
| Abstract: | The immunogenicity of pandemic influenza A H1N1 virus (A/H1pdm) vaccine might be modified by prior seasonal trivalent influenza vaccine (sTIV) administration. We conducted a retrospective analysis of immunogenicity of 243 health care workers (number of sTIV-positive [sTIV+] subjects, 216; number of sTIV− subjects, 27) by hemagglutination inhibition. There was no significant difference in the ratios of antibody titers of ≥40 (41.2% versus 48.1%; P = 0.49) and fold increases in geometric mean titer (3.8 versus 4.5; P = 0.37). sTIV injected 7 to 10 days prior to A/H1pdm vaccine administration did not interfere with the immunogenicity of the latter. |
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