慢性阻塞性肺疾病患者血浆sTM、sEPCR水平变化研究

【目的14g讨血管内皮细胞在慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease，COPD）发生、发展中的损伤变化。【方法】本院呼吸科收治的55例COPD患者分为急性期和稳定期，同时以体检中心30例健康体检者为正常对照，检测其血浆可溶性血管内皮细胞蛋白C受体（Soluble Endothelial Protein CReceptor，sEPCR）、可溶性血栓调节蛋白（Soluble Thrombomdulin，sTM）的变化。【结果】①与正常对照组相比，COPD稳定期和急性期患者sEPCR和sTM水平均明显升高（P〈0．05）。与COPD稳定期患者相比，COPD急性期患者sEPCR、sTM水平均明显升高（P〈0．05）。②与治疗前相比，COPD急性期患者经治疗症状缓解后，血浆sEPCR和sTM水平均明显下降（Pd0．05）。【结论】COPD患者稳定期和急性期均存在内皮细胞损伤。

Changes of Plasma sTM and sEPCR Levels in Patients with Chronic Obstructive Pulmonary Disease

[Objective]To explore the changes of vascular endothelial cell injury in the genesis and development of chronic obstructive pulmonary disease（COPD）. [Methods] Fifty five COPD patients admitted in our hospital were enrolled and divided into acute stage and stable stage. Thirty people from the health examination center were enrolled as control. The changes of plasma soluble endothelial protein C receptor（sEPCR） and sol- uble thrombomodulin（sTM） concentration were detected. [Results] Compared with normal controls, the levels of sEPCR and sTM in COPD patients in stable stage and in acute stage increased significantly（ P 〈0.05）. Compared with COPD patients in stable stage, the levels of sEPCR and sTM in COPD patients in acute stage increased obviously（ P 〈0.05）. Compared with before treatment, the levels of sEPCR and sTM in COPD patients in acute stage decreased obviously（ P 〈0.05）. [Conclusion] Endothelial cell damage can be found in COPD patients in stable and acute stage.