全身炎症反应综合征患儿血管内皮细胞损伤标志物sTM、sEPCR、vWF表达的变化

目的]探讨全身炎症反应综合征(SIRS)患儿血浆血管内皮细胞损伤标志物表达的变化.方法]本院儿科收治的58例SIRS病例为观察组,本院保健门诊体检的健康儿童20例为对照组,检测两组对象血浆可溶性血栓调节蛋白(sTM)、可溶性血管内皮细胞蛋白C受体(sEPCR) 和血管性血友病因子(vWF)的水平及治疗前后变化.结...

Changes of Endothelial Cell injury Indicators sTM, sEPCR and vWF in Children with Systemic Inflammatory Response Syndrome

Objective] To explore the changes of plasma indicators of endothelial cell injury in children with systemic inflammatory response syndrome（SIRS）. Methods] Fifty-eight SIRS children in our hospital were enrolled as observation group, and 20 healthy children in health care department were selected as control. The soluble thrombomodulin（sTM）, soluble endothelial protein C receptor（sEPCR） and yon Willebrand factor （vWF） in plasma were detected in all the subjects of two groups. Results]Compared with healthy controls, plasma sEPCR, sTM and vWF in SIRS patients increased obviously, and there was significant difference（ P 〈0.05）. Compared with before treatment, plasma sEPCR, sTM and vWF in SIRS patients decreased obviously after treatment, and there was also significant difference（ P 〈0.05）. Conclusion]The vascular endothelial cell injury may play an important role in the genesis and development of SIRS.