广东汉族妇女p21基因多态性分布与尖锐湿疣关系的研究

目的:探讨广东汉族妇女p21基因多态性与尖锐湿疣易感性的关系。方法:提取88例HPV16和/或HPV18阳性的尖锐湿疣患者和95例健康对照者的静脉血DNA,分别用RELP的方法检测p21基因型,比较各基因型检出率的差别;并比较不同基因型患者在临床表型方面的差异。结果:患者组Ser/Ser及Ser/Arg的检出率高于健康对照组;皮疹无论为扁平角化样还是乳头瘤样均以Ser/Ser及Ser/Arg的检出率为高。结论:编码Ser的基因可能是尖锐湿疣的易感基因。

The Polymorphism Distribution of p21 and Its Correlation with Clinical Phenotypes in Guangdong Femal Patients with Condyloma Acuminatum

Objective:To investigate the polymorphism distribution of the p21 and its correlation with clinical phenotypes in Guangdong femal patients with condyloma acuminatum.Methods:DNA of the peripheral blood cells from 88 subjects with condyloma acuminatum and 95 healthy controls have been extracted.Genotypes of the p21 were determined by PCR followed by BsmAI restriction endonuclease digestion respectively,then compared to the phenotypes of different p21 genotypic condyloma acuminatum patients.Results:A significant over-representation of the p21 Ser/Ser and Ser/Arg found in cases with condyloma acuminatum.Conclusion:These results suggested that the gene coding Ser may be a risk factor for the susceptibility of the condyloma acuminatum.