Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study |
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Authors: | Huirne J A Hugues J N Pirard C Fischl F Sage J C Pouly J L Obruca A Braat D M van Loenen A C D Lambalk C B |
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Affiliation: | 1 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands, 2 Hôpital Jean Verdier, Reproductive Medicine Center, University Paris XIII, Paris, France, 3 Universite Catholique de Louvain, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium, 4 Allgemeines Krankenhaus, Universitätsklinik für Frauenheilkunde Abteilung Gynäkologischen Endocrinologie und Reproduktions Medicin Spitalgasse 23, Vienna, Austria, 5 Tour Belledonne, Boulevard Maréchal Leclerc 23, Grenoble, 6 Polyclinique Hotel Dieu, Boulevard Charles-de-Gaulle 13, Clermont-Ferrand, France, 7 Kinderwunschzentrum Wien, Lazarettgasse 1618, Vienna, Austria and 8 University Hospital Nijmegen, AZ St Radboud, Obstetrecs-Gynaecology, Geert Grootenplein Zuid 1b, GA Nijmegen, The Netherlands |
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Abstract: | BACKGROUND: The aim of this study was to assess the non-inferiorityof an oral contraceptive (OC)-pretreated cetrorelix regimenand a buserelin regimen in IVF/ICSI patients treated with r-hFSHin terms of total number of oocytes retrieved. METHODS: Multicentre,randomized study. One hundred and eighty two patients were randomizedto receive cetrorelix with OC pretreatment (n = 91) or to receivebuserelin (n = 91). The cetrorelix group started with dailyOCs on cycle day 5 and continued for 2128 days. Cetrorelix(0.25 mg) was given daily from stimulation day 6 up to and includingthe day of r-hCG administration. The buserelin group startedwith buserelin (500 µg/day) for at least 10 days untildown-regulation was achieved, after which the dose was reducedto daily 200 µg up to and including the day of r-hCG administration.r-hFSH was started in both groups on a Friday, in the cetrorelixgroup 5 days after the last OC pill intake. Both regimens werefollowed by a standard IVF or ICSI procedure. The primary efficacyendpoint was the number of oocytes retrieved per patient. RESULTS:Number of oocytes, cancellation rates, r-hFSH requirements,number of oocyte retrievals during the weekend or public holidayand number of pregnancies were similar in both groups. Bothtreatment regimens were well tolerated. CONCLUSIONS: Cetrorelixpretreated with OCs resulted in similar number of oocytes retrievedcompared with a long buserelin protocol. Both regimens werewell tolerated and allowed scheduling of the oocyte retrieval,with only small number of retrievals falling on a weekend orpublic holiday. |
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Keywords: | GnRH agonist/GnRH antagonist/IVF/oral contraceptive/programming |
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