| 甲醛与苯对动物细胞的遗传学效应及联合毒性研究 |
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| 引用本文： | 姚雪梅,叶亚新,王琦. 甲醛与苯对动物细胞的遗传学效应及联合毒性研究[J]. 公共卫生与预防医学, 2006, 17(1): 4-6 |
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| 作者姓名： | 姚雪梅 叶亚新 王琦 |
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| 作者单位： | 苏州科技学院生物系,215009 |
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| 摘 要： | 目的探讨不同浓度的甲醛与苯对小鼠外周血红细胞、骨髓细胞微核的诱发效应。方法甲醛、苯及两者联合作用分高、中、低三个剂量组，采用静吸式染毒方法，每天2h，连续染毒15d，考查微核率的变化。结果染毒后小鼠外周血红细胞、骨髓PCE细胞微核率均明显升高，与对照组相比差异显著。结论甲醛和苯均可不同程度的影响小鼠外周血红细胞和骨髓细胞的微核细胞率，并呈现剂量效应关系，联合作用时效应最强。
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| 关 键 词： | 甲醛 苯 外周血 红细胞 微核 |
| 文章编号： | 1006-2483（2006）01-0004-03 |
| 收稿时间： | 2005-10-20 |
| 修稿时间： | 2005-10-20 |
Heredity Effect of Formaldehyde and Benzene on Animal''''s Cells and Its Combination Toxicity |
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| YAO Xue-mei,YE Ya-xin,WANG Qi. Heredity Effect of Formaldehyde and Benzene on Animal''''s Cells and Its Combination Toxicity[J]. Journal of Public Health and Preventive Medicine, 2006, 17(1): 4-6 |
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| Authors: | YAO Xue-mei YE Ya-xin WANG Qi |
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| Affiliation: | Department of Biology of University of Science and Technology of Suzhou,Suzhou 215009, China |
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| Abstract: | Objective To investigate the effect induced by various concentrations of formaldehyde and benzene on the formation of micronucleus in the periphery blood red cell and marrow polychromatic erythrocyte in mice. Methods Mice were consistently exposed to different doses of formaldehyde and benzene 2 hours a day for 15days ;MN formation rate was detected. Results Compared with the eontrol, MN formation rate increased significantly. Conclusion Different concentrations of formaldehyde and benzene could af- fect the formation of MN of the periphery blood red cell and marrow PCE in mice, which showed a significant dose-related effect, and when used in combination its toxicity was most significant. |
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| Keywords: | PCE |
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