Valproic acid as a promising agent to combat Alzheimer's disease |
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| Authors: | Xiu-Zhen Zhang Xue-Juan Li |
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| Affiliation: | a Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
b Institute of Bioinformatics and State Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China |
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| Abstract: | Alzheimer's disease (AD) is one of the most threatening diseases to the elderly population at present. However, there is no yet efficient therapeutic method to AD. Recently, accumulating evidence indicates that valproic acid (VPA), a widely used mood stabilizer and antiepileptic drug, has neuroprotective potential relevant to AD. Moreover, VPA can induce neurogenesis of neural progenitor/stem cells both in vitro and in vivovia multiple signaling pathways. Therefore, it is suggested that VPA is a promising agent to combat AD. |
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| Keywords: | Aβ, amyloid-β AChE, acetylcholinesterase AD, Alzheimer's disease APP, β-amyloid precursor protein BBB, blood-brain barrier BDNF, brain-derived neurotrophic factor CREB, cyclic AMP response element-binding protein ERK, extracellular signal-regulated kinase GSK-3β, glycogen synthase kinase-3β LEF/TCF, lymphoid enhancer factor/T-cell factor NFTs, neurofibrillary tangles NMDAR, N-methyl- smallcaps" >d-aspartate receptor NSC, neural stem cell PI3K, phosphatidylinositol 3-kinase VPA, valproic acid |
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