Possibility of selection against mtDNA mutations in tumors |
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Authors: | Email author" target="_blank">M?KhaidakovEmail author RJ?Shmookler?Reis |
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Institution: | (1) Department of Geriatrics, University of Arkansas for Medical Sciences, John McClellan Veterans Medical Center, 4300 West 7th Street, Little Rock, AR 72205, USA |
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Abstract: | Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA),
not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations
in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed
to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations
in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied
by active selection against detrimental mtDNA mutations. |
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Keywords: | |
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