|
|||||
|
|
| CD4~+ Notch1~+调节性T细胞和CD4~+ FoxP3~+调节性T细胞 在不明原因复发性流产中的表达 | |
| 引用本文： | 印永祥,韩晓枫,何阳.CD4~+ Notch1~+调节性T细胞和CD4~+ FoxP3~+调节性T细胞 在不明原因复发性流产中的表达[J].中国妇幼保健,2010,25(6). |
| 作者姓名： | 印永祥 韩晓枫 何阳 |
| 作者单位： | 1. 南京医科大学附属无锡市妇幼保健院病理科,江苏,南京,214002 2. 南京医科大学基础医学院 3. 江苏省血液研究所 |
| 摘 要： | 目的:探讨CD4+Notch1+调节性T细胞和CD4+FoxP3+调节性T细胞在不明原因复发性流产(URSA)中的表达。方法:流式细胞术分析复发性流产和正常妊娠动物模型中雌性小鼠CBA/J脾细胞CD4+CD25+Treg、CD4+FoxP3+Treg和CD4+Notch1+Treg的表达百分率变化。结果:流式细胞术分析(FACS)结果显示,相比于正常妊娠组,在复发性流产中CD4+CD25+Treg表达百分率减少、CD4+FoxP3+Treg表达百分率减少、CD4+Notch1+Treg表达百分率增加。结论:Notch1增加与FoxP3表达减少相关,CD4+Notch1+Treg的表达百分率增加可能是URSA的机制之一。 |
| 关 键 词： | 复发性流产 动物模型 CD4 CD25 FoxP3 Notch1 |
Expression levels of CD4+Notch1+regulatory T cells and CD4+FoxP3+ regulatory T cells in unexplained recurrent spontaneous abortion |
|
| YIN Yong-Xiang,HAN Xiao-Feng,HE Yang.Expression levels of CD4+Notch1+regulatory T cells and CD4+FoxP3+ regulatory T cells in unexplained recurrent spontaneous abortion[J].Maternal and Child Health Care of China,2010,25(6). | |
| Authors: | YIN Yong-Xiang HAN Xiao-Feng HE Yang |
| Institution: | YIN Yong-Xiang,HAN Xiao-Feng,HE Yang.Department of Pathology,Maternal , Child Health Hospital of Wuxi,Nanjing Medical University,Wuxi 214002,Jiangsu,China |
| Abstract: | Objective:To explore the expression levels of CD4+Notch1+ regulatory T cells and CD4+ FoxP3+ regulatory T cells in unexplained recurrent spontaneous abortion.Methods:The changes of expression percentages of CD4+CD25+ regulatory T cells,CD4+ FoxP3+ regulatory T cells and CD4+ Notch1+ regulatory T cells in splenic cells of CBA/J female rats of recurrent spontaneous abortion and normal pregnancy were analyzed by flow cytometry.Results:Compared with normal pregnancy group,flow cytometry analysis showed that the... |
| Keywords: | Recurrent spontaneous abortion Animal model CD4 CD25 FoxP3 Notch1 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |