动态血清降钙素、CRP与重症社区获得性肺炎发生、发展及预后的关系

目的 观察血清降钙素（PCT）、C-反应蛋白（CRP）与重症社区获得性肺炎（severe community aquiered pneumonia,SCAP）患者病情发生、发展以及预后的关系,并探讨其临床意义.方法 选择2011年6月至2012年6月我院收治的重症社区获得性肺炎患者以及肺炎患者各44例作为研究对象,给予两组患者常规的抗生素、化痰药物以及营养支持治疗,必要时行无创或者有创的机械辅助通气治疗并给予适量的血管活性药物治疗.在病人人院的第1、3、7天采取其血液标本并且进行血清PCT与CRP的测定.同时比较两组患者住院期间的死亡率.结果 第1天,两组血清PCT水平比较,差异无统计学意义；第3天与第7天两组血清PCT水平比较,差异具有统计学意义,在观察期内,肺炎组的PCT含量逐渐降低,重症肺炎组逐渐增高；第1天、第3天以及第7天两组血清CRP水平比较,差异具有统计学意义,在观察期内,肺炎组的CRP含量逐渐降低,重症肺炎组逐渐增高；两组患者住院期间内死亡事件发生率比较,重症肺炎组显著高于肺炎组,差异具有统计学意义.结论 PCT与CRP对于SCAP患者病情发生、发展以及预后具有重要意义.

The relationship between dynamic serum calcitonic CPR and occurrence development and prognosis of severe community-acguired pneumonia

Objective To observe the relationship of serum calcitonin （PCT） and C-reactive protein （CRP） with the occurrence,development and prognosis of patients with severe community-acquired pneumonia （severe community aquiered pneumonia,SCAP） and explore its clinical significance.Methods Select 44 cases of severe community-acquired pneumonia patients as well as 44 cases of patients with pneumonia adopted in our houpital from June 2011 to June 2012 in our hospital.All the patients were given routine antibiotics,expectorant drugs,nutritional support treatment and non-invasive or invasive mechanical ventilation therapy if necessary.And give the right amount of vasoactive drugs.Blood samples of all the patient were taken at the first 1,3,7 days after they were admitted to our hospital.And make serum PCT and CRP determination with these samples.At the same time compare the mortality of the two groups of patients during hospitalization.Results There was no statistically significant difference on the first day of serum PCT levels of the two groups.While there was statistically significant difference on the third and seventh day of serum PCT levels of the two groups.During the observation period,PCT levels decreased gradually in the pneumonia group while increased gradually in the severe pneumonia group.There was statistically significant difference on the first,third and seventh day of serum CRP levels of the two groups.During the observation period,CRP levels decreased gradually in the pneumonia group while increased gradually in the severe pneumonia group.And the deaths rate during hospitalization of the severe pneumonia group was significantly higher than the pneumonia group.And there was statistically significant difference of the two groups.Conclusion PCT and CRP are of great significance in the process of the occurrence,development and prognosis of patients with SCAP.