| 阿托伐他汀对老年2型糖尿病血脂异常患者颈动脉斑块的影响 |
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| 引用本文： | 刘菊,梅群超,黄婷.阿托伐他汀对老年2型糖尿病血脂异常患者颈动脉斑块的影响[J].微循环学杂志,2011,21(3):57-59,89,92. |
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| 作者姓名： | 刘菊 梅群超 黄婷 |
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| 作者单位： | 华中科技大学同济医学院附属中西医结合医院,武汉市第一医院老年病科,武汉,430022 |
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| 摘 要： | 目的:观察阿托伐他汀对老年2型糖尿病血脂异常患者颈动脉斑块的影响。方法:选择80例2型糖尿病血脂异常患者,随机分为阿托伐他汀治疗组(治疗组,40例)和非阿托伐他汀治疗组(对照组,40例),治疗组每晚顿服阿托伐他汀片10mg,对照组每晚服用一片安慰剂,两组的疗程均为24周。测定两组治疗前和治疗12、24周时患者血脂和血清超敏C-反应蛋白(hs-CRP)水平,并通过彩超观察两组治疗前后颈动脉斑块大小及颈动脉内膜-中层厚度(CI-MT)的变化。结果:治疗12周,治疗组患者胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和hs-CRP均较治疗前明显降低(P<0.05),且颈动脉斑块大小和CI MT较治疗前明显减小(P<0.05),治疗24周时效果更显著(P<0.01)。结论:阿托伐他汀对老年2型糖尿病血脂异常患者具有降脂和抗炎作用,并降低CI MT,减少颈动脉斑块,改善动脉粥样硬化进程。
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| 关 键 词： | 2型糖尿病 血脂异常 阿托伐他汀 颈动脉斑块 |
Effects of Atorvastatin on Carotid Atheroma in Elderly Patients with Type 2 Diabetes with Hyper Lipidaemia |
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| Liu Ju,Mei Qunchao,Huang Ting.Effects of Atorvastatin on Carotid Atheroma in Elderly Patients with Type 2 Diabetes with Hyper Lipidaemia[J].Chinese Journal of Microcirculation,2011,21(3):57-59,89,92. |
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| Authors: | Liu Ju Mei Qunchao Huang Ting |
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| Institution: | Liu Ju,Mei Qunchao,Huang Ting /Department of Geriatrics,The Hospital of Integrative Medicine,Tongji Medical College of Huazhong University of Science and Technology,The First Hospital of Wuhan,Wuhan 430022 |
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| Abstract: | Objective: To observe the effects of atorvastation on carotid atheroma in eldly patients with type 2 diabetes with dyslipidemia.Method: 80 eldly patients with type 2 diabetes with dyslipidemia were selected and randmly divided into two groups.The treatment guoup(n=40) was given oraly 10 microgram of atorvastain every night and the control group was given oraly a placebo every night.Each group received corresponding therapy for 24 weeks.Changes of the serum levels of lipidaemia,hs-CRP and carotid arterial in... |
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| Keywords: | Type 2 diabetes Dyslipidemia Atorvastatin Carotid atheroma |
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