| 冠心病患者高迁移率族蛋白B1水平变化的临床研究 |
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| 引用本文： | 盛蕾,伍琼.冠心病患者高迁移率族蛋白B1水平变化的临床研究[J].微循环学杂志,2011,21(3):62-63,67,89,92. |
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| 作者姓名： | 盛蕾 伍琼 |
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| 作者单位： | 武汉市第五医院心内科,武汉,430000 |
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| 摘 要： | 目的:探讨冠心病(CHD)患者血清高迁移率族蛋白B1(HMGB1)水平变化及其临床意义。方法:CHD患者158例,分为急性冠脉综合征组(ACS组,87例)和稳定型心绞痛组(SA组,71例),选择30例年龄和性别匹配的健康体检者作为对照组,采用ELISA检测各组人群血清HMGB1水平,并同时检测超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)和血脂水平。结果:CHD患者血清HMGB1和hs-CRP水平较对照组明显增高(6.47±1.39ng/ml vs 2.19±0.43ng/ml,P<0.01;3.42±0.87g/ml vs 1.15±0.22g/ml,P<0.01)。ACS组患者血清HMGB1水平显著高于SA组(8.52±2.08ng/ml vs 5.38±1.26ng/ml,P<0.01)。ACS组患者血清hs-CRP水平较SA组和对照组也明显升高。CHD患者血清HMGB1水平与hs-CRP水平呈显著正相关(r=0.685,P<0.01)。结论:血清HMGB1水平的变化在CHD的发病过程中有重要意义,可作为CHD的监测指标之一。
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| 关 键 词： | 高迁移率族蛋白B1 冠心病 炎症 |
The Expression and Significance of HMGB1 in Patients with Coronary Heart Disease |
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| Sheng Lei,Wu Qiong.The Expression and Significance of HMGB1 in Patients with Coronary Heart Disease[J].Chinese Journal of Microcirculation,2011,21(3):62-63,67,89,92. |
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| Authors: | Sheng Lei Wu Qiong |
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| Institution: | Sheng Lei,Wu Qiong/Department of Cardiology,The Fifth Hospital of Wuhan City,Wuhan 430000 |
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| Abstract: | Objective: To investigate the relationship between serum high mobility group box 1 protein(HMGB1) level and coronary heart disease(CHD).Method: A total of 158 CHD patients were enrolled in this study,which include 87 patients with acute coronary syndrome(ACS group) and 71 patients with stable angina(SA group).Thirty age-and sex-matched people without CHD were considered as control group.Serum HMGB1 concentration in CHD patients and healthy people was measured by ELISA.The levels of hs-CRP,WBC and blood lipi... |
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| Keywords: | High mobility group box 1 protein Coronary heart disease Inflammation |
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