| 几种血管活性药物对失血性休克大鼠肠系膜微循环的影响 |
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| 引用本文： | 余上斌,杨莹,柯丹,冯秀玲,晏汉姣.几种血管活性药物对失血性休克大鼠肠系膜微循环的影响[J].微循环学杂志,2011,21(3):19-20,25,88,91. |
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| 作者姓名： | 余上斌 杨莹 柯丹 冯秀玲 晏汉姣 |
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| 作者单位： | 华中科技大学同济医学院机能学中心实验室,武汉,430030 |
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| 摘 要： | 目的:比较几种血管活性药物对失血性休克大鼠肠系膜微循环的影响。方法:选取SD大鼠,随机分为正常对照组(A组),失血性休克模型组(B组),生理盐水处理组(C组),多巴胺处理组(D组),去甲肾上腺素处理组(E组),山莨菪碱处理组(F组)。实验采用动脉放血至动脉血压为60mmHg左右,同时观察肠系膜微循环状态改变来复制失血性休克大鼠模型;各组行相应药物处理后,分别测量动脉血压和检测肠系膜微循环相关指标,并进行比较分析。结果:B组大鼠动脉血压、肠系膜微血管出/入口管径、血流速度明显低于A组(P<0.05或P<0.01),血液流态由线流改变为粒流。与B组比较,几种血管活性药物(D、E、F组)对失血性休克大鼠动脉血压均有显著升高作用,依次为去甲肾上腺素>多巴胺>山莨菪碱(P<0.05或P<0.01),多巴胺对微血管出/入口管径恢复明显(P<0.01),山莨菪碱和多巴胺对肠系膜血流速度有明显改善(P<0.01或P<0.05),山莨菪碱还能使肠系膜血流流态恢复为线流。结论:实验性治疗失血性休克需适度补充血容量,同时选用山莨菪碱改善肠系膜微循环,有利于休克复苏。
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| 关 键 词： | 血管活性药物 失血性休克 微循环 大鼠 |
Effects of Several Vasoactive Agent on Intestines Mesentery Microcirculation in Haemorrhagic Shock Rat |
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| Yu Shangbin,Yang Ying,Ke Dan,et al/Center Laboratory of Functional Science,Tongji Medical College,Huazhong University of Science , Technology,Wuhan.Effects of Several Vasoactive Agent on Intestines Mesentery Microcirculation in Haemorrhagic Shock Rat[J].Chinese Journal of Microcirculation,2011,21(3):19-20,25,88,91. |
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| Authors: | Yu Shangbin Yang Ying Ke Dan /Center Laboratory of Functional Science Tongji Medical College Huazhong University of Science Technology Wuhan |
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| Institution: | Yu Shangbin,Yang Ying,Ke Dan,et al/Center Laboratory of Functional Science,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective: To investigate the effect of three vasoactive drugs on mesenteric microcirculation during hemorrhagic shock.Method: Male Sprague-Dawley rats were divided into 6 groups which were control group(group A),hemorrhagic shock group(group B),hemorrhagic shock group with normal saline treatment(group C),hemorrhagic shock group with dopamine treatment(group D),hemorrhagic shock group with noradrenalin treatment(group E),hemorrhagic shock group with anisodamine treatment(group F).Method of bloodletting to ... |
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| Keywords: | Vasoactive agent Haemorrhagicshock Microcirculation Rat |
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