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Lack of evidence for a role of endorphinergic mechanisms in mediating a discriminative stimulus produced by diazepam in rats
Authors:Gary T. Shearman  Mark J. Millan  Albert Herz
Affiliation:(1) Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 2, D-8000 München 40, Federal Republic of Germany
Abstract:Male Sprague-Dawley rats were trained in a two-lever food-reinforced procedure to discriminate between the effect of saline and diazepam (2.5 mg/kg). After acquisition of this discrimination, the ability of morphine to generalize, and naloxone to antagonize the diazepam discriminative stimulus was tested. The rats did not generalized the effect of morphine, and naloxone did not antagonize the diazepam discriminative stimulus whether it was given prior or subsequent to diazepam. These data suggest a lack of involvement of endorphins in mediating the discriminative stimulus property of diazepam.
Keywords:Discriminative stimulus  Diazepam  Morphine  Naloxone  Endorphins  Rat
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