A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells |
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| Authors: | Abe Masakazu Sugiura Tsuyoshi Takahashi Miho Ishii Kotaro Shimoda Miyuki Shirasuna Kanemitsu |
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| Affiliation: | Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. |
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| Abstract: | In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay and the cell aggregation assay revealed that CD82 strengthens E-cadherin-mediated intercellular adhesion. Interestingly, ectopic expression of CD82 stabilized E-cadherin/beta-catenin complex formation. Furthermore, CD82 reduced tyrosine phosphorylation of beta-catenin on HGF stimulation. Taken together, CD82 may stabilize or strengthen E-cadherin-dependent intercellular adhesion by regulating beta-catenin-mediated signal transduction on cancer cells, and consequently, prevent cancer cells from seceding from the primary tumor site. |
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| Keywords: | CD82/KAI-1 E-cadherin β -Catenin Cancer invasion Cell adhesion |
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