生物软组织链式结构的力学性质

目的应用一种新的方式描述软生物组织结构,进而研究组织中胶原纤维的力学性质。将一种虫式模型应用于描述胶原微纤维的力学行为。方法应用虫式模型分析了八链体胞的各向异性影响。所用模型在微观层次上,基于长链分子的统计学特性;在宏观层次上,则通过引进一个特征材料主轴方向上横观各向同性八链体胞模型来描述胶原链网状结构。结果以上述模型为基础分析了软组织结构的力学性质,得到了各向异性八链体胞模型的应力应变曲线。结论八链体胞模型对体胞尺度和加载角度有敏感的反应,如果能加入一些生理材料参数,模型将不仅能模拟生物软组织的消极行为,而且能模拟软组织对于力学加载环境的主动响应。

Micromechanical character of chain structure for biological tissue

Objective A new method is used to describe the structure of biological tissue, and research the mechanical character of collagen fibre in the tissues. Methods A wormlike chain model is applied to capture the behavior of the collagen microfibrils. On the microlevel, the model used is basing on the statistics of long chain molecules; and on the macrolevel, the network of collagen chains is represented by a transversely isotropic eight chain unit cell introducing one characteristic material axis. Results At that event, the worm like chain model is chosen to analyse the mechanics character of biological tissue structure, and we get the force vs. elongation response curves of the wormlike chain model with anisotropy in an eight chain unit cell. Conclusion The eight chain unit cell has scaling and loading angle sensitivity. If the present model is governed by a limited number of physically motivated material parameters, it is believed to be ideally suited to simulate not only the passive behavior of soft biological tissues but also their active response to changes in the mechanical loading environment.