| 内皮脂酶与高密度脂蛋白代谢 |
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| 引用本文： | 萨仁高娃,朱清,吴明绘.内皮脂酶与高密度脂蛋白代谢[J].中国动脉硬化杂志,2012,20(1):80-84. |
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| 作者姓名： | 萨仁高娃 朱清 吴明绘 |
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| 作者单位： | 山东大学齐鲁医院心内科,山东省济南市,250012 |
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| 摘 要： | 内皮脂酶是近年来发现的甘油三酯脂肪酶基因家族新成员.该家族还包括脂蛋白脂肪酶、肝脂肪酶.内皮脂酶具有磷脂酶活性,可参与脂蛋白代谢,尤其对血浆中的高密度脂蛋白代谢及高密度脂蛋白胆固醇水平具有明显调节作用.近来研究证明,抑制内皮脂酶可提高人血浆高密度脂蛋白胆固醇水平.但目前内皮脂酶与高密度脂蛋白胆固醇、胆固醇逆行转运及动脉粥样硬化之间的关系仍尚无明确定论,且有待进一步研究.
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| 关 键 词： | 内皮脂酶 高密度脂蛋白 高密度脂蛋白胆固醇 动脉粥样硬化 |
| 收稿时间： | 2011/6/14 0:00:00 |
Endothelial Lipase in High Density Lipoprotein Metabolism |
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| SA Rengaow,ZHU Qing,and WU Ming-Hui.Endothelial Lipase in High Density Lipoprotein Metabolism[J].Chinese Journal of Arteriosclerosis,2012,20(1):80-84. |
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| Authors: | SA Rengaow ZHU Qing and WU Ming-Hui |
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| Institution: | 1(1.Department of Cardiology,Qilu Hospital of Shandong University,Jinan,Shandong 250012,China) |
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| Abstract: | Endothelial lipase(EL) is a new identified member of the lipase family,which includes lipoprotein lipase(LPL) and hepatic lipase(HL).EL is a phospholipase that plays an important role in lipoprotein metabolism,mainly regulation of plasma high density lipoprotein(HDL) metabolism and HDL cholesterol(HDLC) levels.Previous data has been reported that inhibition of EL in humans expected to increase the HDLC level.However,an important challenge is to determine how EL affects HDLC levels,reverse cholesterol transport(RCT) and progression of atherosclerosis(As). |
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| Keywords: | Endothelial Lipase High Density Lipoprotein High Density Lipoprotein Cholesterol Atherosclerosis |
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