GALNT2基因多态性与血脂及心血管疾病关系的研究进展

GALNT2基因属于多肽-N-乙酰氨基半乳糖转移酶家族(简称GalNAc-Ts),其主要功能是参与O-糖基化的第一步反应。目前最新GWAS研究报道GALNT2基因单核苷酸多态性可影响高密度脂蛋白胆固醇及甘油三酯水平,是心血管疾病易感基因之一。因此GALNT2的功能、遗传差异及与心血管疾病的关系将成为今后研究的一个热点。本文较全面的阐述了GALNT2的生物学特性、功能以及GALNT2基因多态性与心血管疾病的关系。

Research Progress of the Relationship of GALNT2 Gene Polymorphism with Lipids Levels and Cardiovascular Diseases

GALNT2 is a key member of polypeptide:N-acetylgalactosaminyltransferase family(GalNAc-Ts),and recent GWAS based epidemiological study reveal that its polymorphism can interrupt HDLC and TG levels in blood,and is significantly associated with cardiovascular disease.GALNT2 participates in the first step of O-linked glycosylation and is regarded as a cardiovascular disease susceptible gene recently.Therefore,its function and genetic difference as well as the relationship with cardiovascular disease will become a hot research point in the future.This review will focus on the recent advances in research of its biological characteristics,functions,gene polymorphisms and relationship with lipids levels and cardiovascular disease.