中老年人群类风湿关节炎合并心血管疾病的相关因素分析

目的 探讨类风湿关节炎患者合并心血管疾病可能的危险因素.方法 回顾性分析唐山市工人医院179例均符合美国风湿学会标准的类风湿关节炎患者的患病情况和心血管疾病危险因素,探讨类风湿关节炎合并心血管疾病的危险因素.结果 单因素分析提示类风湿关节炎合并心血管疾病发生的风险与年龄、类风湿关节炎病程、内膜中膜厚度、DAS28评分、关节外脏器受累数、类风湿因子、血小板计数、C反应蛋白和总胆固醇水平有关(P＜0.05)；多因素分析提示类风湿关节炎合并心血管疾病发生的风险与DAS28病情活动性评分(OR=2.403)、关节外脏器受累数(OR=1.197)、类风湿因子(OR =2.510)、血小板计数(OR=1.166)、C反应蛋白(OR=1.700)和总胆固醇(OR=1.351)有关,与其他传统心血管疾病危险因素无关.结论 类风湿关节炎增加了心血管疾病发生的风险,为治疗和预防心血管疾病方面提供部分依据.

Risk Factors Assessment of Cardiovascular Disease in Old Patients with Rheumatoid Arthritis

Aim To assess the risk factors of cardiovascular disease(CVD)in the patients with rheumatoid arthritis(RA). Methods We analysed the prevalence of 179 patients with RA who met the revised American College of Rheumatology(ACR) criteria and evaluated the risk factors of CVD patients with RA. Results One-factor analysis shows the risk in CVD of RA was associated with age,process of RA,intima-media thickness(IMT),DAS28 disease activity score,number of involved extra-articular organs,rheumatoid factor(RF),platelet count,C-reactive protein(CRP) and total cholesterol(TC)level(P<0.05).Multi-factor analysis indicates the risk in CVD of RA was associated with DAS28 disease activity score(OR=2.403),number of involved extra-articular organs(OR=1.197),RF(OR=2.510),platelet count(OR=1.166),CRP(OR=1.700) and TC(OR=1.351),and was not associated with other traditional CVD risk factors. Conclusion Our data suggest a higher risk of cardiovascular events patients with RA,providing the basis of treatment and prevention of CVD.