| 基于分子对接技术探讨中药抑制人胰脂肪酶活性的潜在物质基础以及用药规律研究 |
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| 引用本文： | 欧海亚,叶小鹏,纪意纯,刘嘉辉,邝卫红,程宏辉. 基于分子对接技术探讨中药抑制人胰脂肪酶活性的潜在物质基础以及用药规律研究[J]. 世界科学技术-中医药现代化, 2021, 23(11): 4211-4221 |
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| 作者姓名： | 欧海亚 叶小鹏 纪意纯 刘嘉辉 邝卫红 程宏辉 |
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| 作者单位： | 广州中医药大学附属宝安中医院 深圳 518133;中山大学附属第一医院 广州 510080;广东医科大学第二临床医学院 湛江 524000 |
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| 基金项目： | 补充立项部门补充基金类型（编号）：课题名称,负责人：XXX。 |
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| 摘 要： | 目的 探讨中药抑制人胰脂肪酶(Human pancreatic lipase,HPL)活性的潜在物质基础以及用药规律.方法 以OB(oral bioavailability)≥30％、DL(drug likeness)≥0.18、Lipinski类药五原则及Verb原则为条件从TCMSP数据库中筛选出化合物并构建配体数...
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| 关 键 词： | 肥胖 人胰脂肪酶 分子对接 物质基础 用药规律 新药开发 |
| 收稿时间： | 2021-02-21 |
| 修稿时间： | 2022-01-04 |
Based on Molecular Docking Technology to Explore the Potential Material Basis and Medication Rules of Herbs in Inhibiting Human Pancreatic Lipase (HPI) Activity |
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| Ou Haiy,Ye Xiaopeng,Ji Yichun,Liu Jiahui,Kuang Weihong and Cheng Honghui. Based on Molecular Docking Technology to Explore the Potential Material Basis and Medication Rules of Herbs in Inhibiting Human Pancreatic Lipase (HPI) Activity[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2021, 23(11): 4211-4221 |
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| Authors: | Ou Haiy Ye Xiaopeng Ji Yichun Liu Jiahui Kuang Weihong Cheng Honghui |
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| Affiliation: | Baoan Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518133, China,Baoan Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518133, China,Baoan Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518133, China,The First Affiliated Hospital, SUN Yat-sen University, Guangzhou 510080, China,The Second Clinical Medical College of Guangdong Medical University, Zhanjiang 524000, China,Baoan Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518133, China |
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| Abstract: | |
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| Keywords: | Obesity Human pancreatic lipase Molecular docking Material basis Medication rule New drug development |
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