Cross-modal innervation of primary visual cortex by auditory fibers in congenitally anophthalmic mice |
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Authors: | Laemle L K Strominger N L Carpenter D O |
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Affiliation: | Department of Ophthalmology, UMDNJ-New Jersey Medical School, 30 Bergen Street, Rm. 1409, Newark, NJ 07103, USA. laemlelb@umdnj.edu |
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Abstract: | Auditory-visual cross-modal innervation was examined in control (sighted, ZRDCT-N) and congenitally anophthalmic (eyeless, ZRDCT-AN) mice using electrophysiological recording and pathway tracing with carbocyanine dyes. Electrophysiological data demonstrate that the primary visual cortex of congenitally eyeless, blind, mice receives auditory stimuli. Neuroanatomical data demonstrate a direct connection between the inferior colliculus (IC) and visual cortex. Our experiments provide new information about how the brain adapts to the loss of sight. |
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Keywords: | Cross-modal innervation Visual cortex Auditory pathway Anophthalmic mice |
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