Vinblastine-induced autophagocytosis: the effect of disorganization of microfilaments by cytochalasin B |
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Authors: | Yrjö Hirsimäki Pirkko Hirsimäki |
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Institution: | Department of Cell Biology, University of Jyväskylä, Vapaudenkatu 4, SF-40100 Jyväskylä 10, Finland |
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Abstract: | The effects of disorganization of cellular microfilaments by cytochalasin B on vinblastine-induced autophagocytosis was studied in Ehrlich ascites tumor cells in vitro. Incubation with vinblastine induced a formation of autophagic vacuoles in the cytoplasm. The disorganization of microfilaments by cytochalasin B failed to inhibit vinblastine-induced autophagocytosis. Incubation with cytochalasin B alone induced a rapid formation of blebs on the cell surface. These contained cytoplasmic organelles and were connected by a narrow shaft to the main part of the cell. Thin subcortical microfilaments seen in the control cell cytoplasm were apparently relocated after cytochalasin B treatment and formed amorphous masses deeper in the cytoplasm. Vinblastine did not affect the formation of blebs after cytochalasin B treatment. |
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