| 硒对砷毒性的拮抗作用研究 |
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| 引用本文： | 戴宇飞, 陈艳, 高耘, 邢彩虹, 张林林, 李桂兰. 硒对砷毒性的拮抗作用研究[J]. 中国公共卫生, 2002, 18(10): 1187-1189. DOI: 10.11847/zgggws2002-18-10-22 |
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| 作者姓名： | 戴宇飞 陈艳 高耘 邢彩虹 张林林 李桂兰 |
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| 作者单位： | 1.中国疾病预防控制中心职业卫生与中毒控制所 北京10005 |
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| 摘 要： | 目的研究硒对砷毒性的拮抗作用。方法建立大鼠砷中毒模型及硒砷联合染毒模型,测定大鼠血砷含量、血细胞计数及血液生化指标,对主要脏器进行病理组织学检查。结果硒砷联合染毒组的大鼠血砷含量明显低于砷中毒组;当硒剂量达100μg/kg·bw时,对砷中毒导致的红细胞数下降、血红蛋白含量降低、血液巯基总量下降、脾肿大、肺、肝、肾等组织的病理学改变具有一定的保护作用。结论硒可以促使砷从血液中排出,对砷毒性具有一定的拮抗作用。
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| 关 键 词： | 砷中毒 硒 拮抗作用 |
| 文章编号： | 1001-0580(2002)10-1187-03 |
| 收稿时间： | 2001-08-29 |
| 修稿时间： | 2001-08-29 |
Antagonism of Selenium on Arsenic Toxicity |
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| DAI Yu-fei, CHEN Yan, GAO Yun, . Antagonism of Selenium on Arsenic Toxicity[J]. Chinese Journal of Public Health, 2002, 18(10): 1187-1189. DOI: 10.11847/zgggws2002-18-10-22 |
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| Authors: | DAI Yu-fei CHEN Yan GAO Yun |
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| Affiliation: | 1.Institute for Occupational Health and Poison Control, National Center for Disease Prevention and Control, Beijing 100050, China |
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| Abstract: | ObjectiveTo investigate the antagonism of selenium on arsenic toxicity.MethodsMale Wistar rats were treated with arsenic trioxide and coadministration of arsenic trioxide and selenium compound.Clinical examinations included concentration of arsenic and selenium,hematology,biochemistry determination on blood and histopathologic examination.ResultsConcentration of arsenic in blood of coadministered group was significantly lower than that in arsenic poisoning group; Selenium at dose of 100μg/kg·bw can weaken some toxic effects of arsenic,such as decrease of erythrocyte count,hemoglobin contents and total concentration of hydrosulfide group in blood,spleen swelling,pathological damages to the liver,kidney and lung.ConclusionSelenium could promote the excretion of arsenic from blood,and antagonize toxicity of arsenic. |
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| Keywords: | arsenic poisoning selenium antagonism |
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