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Humanα 2-macroglobulin gene is located on chromosome 12 |
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| Authors: | Graeme I. Bell Leslie B. Rall Ray Sanchez-Pescador James P. Merryweather James Scott Roger L. Eddy Thomas B. Shows |
| Affiliation: | (1) Chiron Corporation, 4560 Horton Street, 94608 Emeryville, California;(2) Molecular Medicine Group, MRC, Clinical Research Centre, HAI 3UJ Harrow, Middlesex, UK;(3) Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, 14263 Buffalo, New York |
| Abstract: | A cDNA clone encoding amino acids 809–1451 of the protease inhibitor  2-macroglobulin has been isolated from an adult human liver cDNA library. This cDNA was used to examine DNA samples prepared from a panel of human-mouse somatic cell hybrids with different numbers and combinations of human chromosomes for the presence of the human 2-macroglobulin gene. The cosegregation of this gene and chromosome 12 in the cell hybrid panel indicated that the 2-macroglobulin structural gene (designated A2M) is on human chromosome 12. |
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