Inhibition of growth of human lung adenocarcinoma cell lines by anti-transforming growth factor-alpha monoclonal antibody |
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| Authors: | K Imanishi K Yamaguchi M Kuranami E Kyo T Hozumi K Abe |
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| Affiliation: | Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan. |
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| Abstract: | We previously reported that two human lung adenocarcinoma cell lines (A-549 and PC-9) produce human transforming growth factor-alpha (hTGF-alpha) and express its receptors. In the present study an exogenously added monoclonal antibody against recombinant hTGF-alpha inhibited growth of these cell lines in vitro. This result indicated that endogenous hTGF-alpha produced by the cancer cells can function as an autocrine growth factor. |
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