非酒精性脂肪肝血清丙氨酸氨基转移酶与代谢综合征及其组分关系

目的探讨非酒精性脂肪性肝病患者血清丙氨酸氨基转移酶（ALT）和代谢综合征及其组分的关系。方法104例非酒精性脂肪肝患者分成血清ALT升高组和正常组，分析两组的人口学特征、生化指标及代谢综合征患病率和组分，采用二分类logistic回归分析评价非酒精性脂肪肝患者发生血清ALT升高的危险因数。结果非酒精性脂肪肝ALT升高组与正常组的腹围、体重指数、空腹胰岛素、HOMA-IR、血清天冬氨酸氨基转移酶（AST）、γ-谷氨酰转肽酶（r-GT）、尿酸有显著的统计学差异（P〈0．05），两组代谢综合征和组分患病率比较显示ALT升高组的高脂血症患病率高（P〈0．05）。非酒精性脂肪肝ALT升高和性别、年龄、高尿酸血症密切相关（P〈0．05）。高尿酸血症是非酒精性脂肪肝ALT升高的独立危险因数（P〈0．05）。结论NAFLD血清ALT水平和MS及其组分密切相关，同时可作为胰岛素抵抗和心血管疾病发生危险的指标。高尿酸血症是非酒精性脂肪肝ALT升高的独立危险因数。

The relationship of serum ALT in non-alcoholic fatty liver disease with metabolic syndrome and its components

Objective To explore the relationship of serum ALT in non-alcoholic fatty liver disease with metabolic syndrome and its components. Methods 104 patients with non-alcoholic fatty liver disease were divided into two groups including elevated serum ALT and normal serum ALT. Compared two groups demographic characteristics, biochemical, metabolic syndrome and its components. Using binary logistic regression analysis risk factors of non-alcoholic fatty liver patients with high ALT levels. Results Abdominal circumference, BMI, FIN, HOMA-IR, AST, y-GT, UA in non-alcoholic fatty liver dingease with elevated ALT group were higher than normal group,there were significant differences （P〈0.05） . High prevalence of hyperlipidemia in elevated serum ALT group （P〈0.05）. Hyperuricemia was an independent risk factor for non-alcoholic fatty liver disease with high ALT levels （P〈0.05）. Gender, age, high serum uric acid is closely related elevated ALT in non-alcoholic fatty liver and （P〈0.05）. Hyperuricemia was independent risk factor for non-alcoholic fatty liver diease patients with high ALT levels （P〈0.05）. Conclusions Serum ALT levels of NAFLD was closely related to MS and its components. Serum ALT level may be a marker of insulin resistance and cardiovascular disease. Hyperuricemia was independent risk factor for non-alcoholic fatty liver diease patients with high ALT levels.