丹参对大鼠环孢素A慢性肾毒性的保护作用

目的：为提高同种肾移植术后患者的长期存活率，研究丹参对环孢素A(CsA)慢性肾毒性的防护作用。方法：观察大鼠灌服CsA及低盐饮食28d，肾功能、病理和转化生长因子-(TGF-β1)免疫组化的改变及复方丹参注射液对上述改变的防护作用。结果：CsA能诱导大鼠肾小球滤过率下降，增加尿中N-乙酰-β-D-氨基葡萄糖苷酶(NAG)的排泄，引起肾间质纤维化和小动脉病变等。丹参能改善上述病变，减低肾内TGF-β1的表达。结论：丹参对CsA的慢性肾毒性有明显的防护作用。

Prevention of experimental cyclosporin-induced chronic nephrotoxicity byradix salviae miltiorrhizae

Aim: To enhance long-term success rates for recipients of cadaver kidney transplantation and investigate the effectof radix salviae miltiorrhizae on cyclosporin-induced chronic nephrotoxicity. Methods: Rats were on low-salt diet and cyclosporineA (CsA) was administered once a day by gastric gavage at doses of 30 mg/(kg·d) for 28 days. Renal functional and morphologi-cal changes were assessed. The effects of radix salviae miltiorrhizae on these changes were also evaluated. Results: Characteristichistological changes of proximal tubular injury, tubulointerstitial fibrosis developed in CsA-treated rats. They were accompanied byphysiological changes of decreased creatinine clearance, impaired renal concentrating ability and increased tubular enzymuria.Radix salviae miltiorrhizae could reduce these changes significantly. Conclusion: Radix salviae miltiorrhizae may be useful forprevention of cyclosporin-induced chronic nephrotoxicity.