胰岛素和氨茶碱影响针麻效果的临床观察

<正> 大量研究资料反复证明,脑内5-羟色胺(5-HT)能神经元系统在针刺镇痛中有着重要作用。激活或加强这个系统的神经传递,针刺镇痛效应得到提高;相反,破坏或减弱这个系统的神经传递,则针刺镇痛效应明显降低。我们以往的动物实验结果表明,胰岛素和氨茶碱在提高脑内5-HT含量的同时,可明显提高大白鼠的针刺镇痛效应。为了验证上述动物实验结果,并探索提高临床针麻效果的可能途径,我们用双盲法观察了胰岛素和氨茶碱对临床针麻效

CLINICAL OBSERVATION ON THE EFFECT OF INSULIN AND AMINOPHYLLINE ON ACUPUNCTURE ANESTHESIA

Eor the purpose of verifying the experimental result that insulin and aminophylline could enhancethe analgesic effect of acupuncture in rats, 326 cases of abdominal tuboligation under acupuncture anest-hesia were observed clinically. Preoperative forecast of the effect of acupuncture anesthesia was madein all cases. Operation began after 20-30 min. induction with electrical needling "Ciliao", bilaterally.The efficiency of acupuncture anesthesta was scored according to the national unified 4-grade system aswell as to the multi-physiological parameters (mainly plethysmogram, combined with respiration, elect-romyogram, GSR and perspiration). Furthermore, the efficiency of acupuncture anesthesia was compa-red with the preoperative forecast, and the rate of transformation of the efficiency of acupuncture ane-sthesia was calculated. The observations were carried out by a double-blind method. The cases were divided into 5 groups(Insulin 8 units s. c., Insulin 12 units s. c., Aminophylline 0.2 gm p. o., Aminophylline 0.3 gm p. o.and local anesthesia) with their respective controls. The control of insulin group received saline s. c. asplacebo, while in the case of aminophylline the placebo was vitamin B_1 p. o. The drugs and placeboswere administered 1 hour before the operation. The results indicate that administration of aminophylline 0.2 gm enhances signilicantly the efficie-ncy of acupuncture anesthesia. Thus, the rate of excellence (Grade I) (71.43%) was greater as compa-red with the control group (42.86%) in 4-grade system, while according to the multi-physiological para-mters the excellence-good rate (Grade I+II) (100%) was greater than that of the control group (86.67%).The rate of transformation of the efficiency of acupuncture anesthesia was also greater than its controlgroup. Similar results were obtained in the Aminophylline 0.3 gm group. On the contrary, in both thegroups of insulin 8 and 12 units the efficiency of acupuncture anesthesia was not greater significantlyas compared with the control groups.